Stem Cell Therapies are well researched and hold

promise in many areas of medicine.

Stem Cells & Arthritis

Trial results suggest that cord blood stem cells may have important therapeutic value for patients with psoriatic arthritis, particularly for those who cannot tolerate standard treatments.

Tissue Eng Part A (2013) Repair of Cartilage Defects in Arthritic Tissue with Differentiated Human Embryonic Stem Cells. (PubMed: 24028447)
Role of stem cells in spondyloarthritis
The potential role of adult stem cells in the management of the rheumatic diseases
Umbilical cord blood stem cell treatment for a patient with psoriatic arthritis
Cartilage Regeneration in Osteoarthritic Patients by a Composite of Allogeneic Umbilical Cord Blood-Derived Mesenchymal Stem Cells and Hyaluronate Hydrogel
Comparison of the efficacy of bone marrow mononuclear cells and bone mesenchymal stem cells in the treatment of osteoarthritis in a sheep model
Intra-Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee
Thrombospondin-2 Secreted by Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Promotes Chondrogenic Differentiation
Treatment of Knee Osteoarthritis With Allogeneic Bone Marrow Mesenchymal Stem Cells
Centers for Disease Control and Prevention. Prevalence of Doctor-Diagnosed Arthritis and ArthritisAttributable Activity Limitation – United States, 2010-2012. MMWR 2013;62:869-873

Stem Cells & Autoimmune Disorders

The incidence and prevalence of inflammatory bowel disease is increasing in Western countries. Current therapies, ranging from anti- inflammatory drugs, immunosuppressive regimens to new biological therapies, remain inadequate.

Stem Cells & Orthopedics

Chronic low back pain is one of the major causes of disability and thus has a major socioeconomic impact. Intervertebral disc degeneration is the main cause of chronic low back pain. Treatment for chronic discogenic low back pain has traditionally been limited to either conservative management or surgical fusion. Recent clinical outcomes indicate that human umbilical cord tissue-derived mesenchymal stem cell transplantation is a favorable alternative method for the treatment of chronic discogenic low back pain.

Stem Cells & Diabetes

While the regenerative potential of stem cells can be harnessed to make available a self-replenishing supply of glucose-responsive insulin-producing cells, their immunomodulatory properties may potentially be used to prevent, arrest, or reverse autoimmunity, ameliorate innate/alloimmune graft rejection, and prevent recurrence of Type 1 diabetes.

Stem Cells & Kidney Function

Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease worldwide. Excess accumulation of extracellular matrix and the epithelial-to-mesenchymal transition contribute to renal fibrosis, which is associated with DKD. Delayed treatment with human umbilical cord blood–derived stem cells may show a therapeutic effect on DKD progression.

Stem Cells & Neurology

Human umbilical cord blood cells (HUCBCs), a prolific source of non-embryonic or adult stem cells, have emerged as effective and relatively safe immunomodulators and neuroprotectors, reducing behavioral impairment in animal models of Alzheimer’s disease (AD), Parkinson’s disease, amyotrophic lateral sclerosis, traumatic brain injury, spinal cord injury, and stroke.

Stem Cells & Osteoarthritis

Intra-articular injection of mesenchymal stem cells into the osteoarthritic knee improved function and pain of the knee joint without causing adverse events. Radiological, arthroscopic, and histological measures consistently demonstrated decreased of articular cartilage defects by regeneration of hyaline-like articular cartilage. These results are promising to encourage large randomized clinical trials, and there is optimism about this new step for the treatment of osteoarthritis of the knee.

Stem Cells & Skin Trauma/Disease

Burn injuries represent one of the major worldwide public health problems causing more severe physiological stress than other traumas. Effective treatment of burn injuries is mandatory to prevent the numerous life-threatening complications and possible disabilities. Stem cells, a population of multipotent cells retaining the properties of self-renewal and differentiation, are the main player in tissue regeneration after major trauma.

Stem Cells & Stroke

Intravenously administered HUCBC enter brain, survive, migrate, and improve functional recovery after stroke. HUCBC transplantation may provide a cell source to treat stroke.

Stem Cells & Wharton's Jelly

Wharton’s jelly is a gelatinous substance that provides insulation and protection within the umbilical cord. Stem cells are present in Wharton’s jelly, as well as in umbilical cord blood.
Both Wharton’s jelly and cord blood stem cells contain mesenchymal stem cells (MSC), while cord blood stem cells also contain hematopoietic stem cells as well as other non-hematopoietic stem cells. When compared to cord blood, Wharton’s jelly may have a more homogenous population of MSCs. Because Wharton’s jelly appears to have less cell variability, it is considered homogenous; while cord blood appears to have more variability and is therefore considered heterogeneous.

Stem Cells & Cancer

Cellular immunotherapy involving the adoptive transfer of immune cells that potently recognize and eliminate malignantly transformed cells has become a promising new tool in the anticancer armory. Studies suggest that the unique biological properties of umbilical cord blood (UCB) cells could precipitate enhanced anticancer activity; hence, UCB could be an optimal source for immunotherapy with the potential to provide products with “off-the-shelf” availability.

Stem Cells & Cardiovascular Disease

Cardiovascular disease constitutes a major cause of morbidity and mortality worldwide, and it is important to develop new therapeutic strategies to reduce its immense social and economic impact. Stem cell therapy has shown promising results in several pre-clinical studies and clinical trials that have reported the safety and efficacy of cell transplantation for a wide range of therapeutic applications.

Stem Cells & Dentistry

New technologies that facilitate solid alveolar ridge augmentation are receiving considerable attention in the field of prosthodontics because of the growing requirement for esthetic and functional reconstruction by dental implant treatments. Recently, several studies have demonstrated potential advantages for stem-cell-based therapies in regenerative treatments.